From Chapter 9:
Later again when the "couple o' Sawbones," the medical students, Ben Allen and Bob Sawyer, make their first appearance on the scene, they are discovered in the morning seated by Mr. Wardle's kitchen fire, smoking cigars; and it is significant of how smoking out of doors was then regarded that Dickens, going on to describe Sawyer in detail, refers to "that sort of slovenly smartness, and swaggering gait, which is peculiar to young gentlemen who smoke in the streets by day, shout and scream in the same by night, call waiters by their Christian names, and do various other acts and deeds of an equally facetious description." Apparently in 1836 the only person who would allow himself to be seen smoking in the street was of the kind naturally inclined to do the other objectionable things mentioned. The same idea runs through the allusions to tobacco in "Pickwick." smoking was undeniably vulgar. Mr. John Smauker, who introduces Sam Weller at the "friendly swarry" of the Bath footmen, smokes a cigar "through an amber tube"—cigar-holders were a novelty. When Mr. Pickwick is taken to the house of Namby, the sheriffs' officer, the "principal features" of the front parlour are "fresh sand and stale tobacco smoke." One of the occupants of the room is a "mere boy of nineteen or twenty, who, though it was yet barely ten o'clock, was drinking gin and water, and smoking a cigar, amusements to which, judging from his inflamed countenance, he had devoted himself pretty constantly for the last year or two of his life." Tobacco-smoke pervades the Fleet prison. In fact, to trace tobacco through the pages of "Pickwick" is to realize vividly how vulgar if not vicious an accomplishment smoking was considered by the fashionable world and how popular it was among the nobodies of the unfashionable world.

From Chapter 1:
Wherever Raleigh is known to have lived or lodged we are sure to find the tradition flourishing that there he smoked his first pipe. The assertion has been made of his birthplace, Hayes Barton, although it is very doubtful if he ever visited the place after his parents left it, some years before their son had become acquainted with tobacco; and also with more plausibility of his home at Youghal, in the south of Ireland. Froude, in one of his "Short Studies," quotes a legend to the effect that Raleigh smoked on a rock below the Manor House of Greenaway, on the River Dart, which was the home of the first husband of Katherine Champernowne, afterwards Raleigh's wife; and Devonshire guide-books have adopted the story.